Antonio Lazcano "The origin and nature of first life" his article
Schrödinger "What is life?" (1994)
Avery, Oswald T., Colin M. MacLeod, and Maclyn McCarty. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Journal of Experimental Medicine 79: 137-158, 1944.
At the time, no books on the life.
What is life (how did it originate) ?
1) autopoiesis
2) self-organization & complex system (popular among physicists, not biologists)
3) emergence of genetic informations & Darwinian evolution
● cyanobacteria: autpoietic system but not enough for life
● complex organization is not unique to living systems
cellular automata
flowing fluids
falling droplets
Belousov-Zhabotinsky reaction (BZ reaction) (video)
"No single rule for all these"
● self-organization of prebiotic components must have been important
● genetic information & physical/chemical laws are necessary
● history's contingency is involved
● physical system is complex, but lacks genetic systems, historical continuity, ie, genealogy
● some systems may have genealogy but not genetic (eg, roman kings)
origin of life
prebiotic evolution -----> ? <------ a="" about="" are="" biological="" evolution="" href="http://en.wikipedia.org/wiki/Oparin" knows="" nobody="" only="" process="" target="_blank" theories="" there="" this="">Oparin's theory is most reliable
Stanley Miller experiment (1953) 不当に批判された
CO2, CO, N2, H2S, H2O, CH4 ---> aa, nucleobases, sugars, lipids, oligomers of biochemical compounds
autocatalytic systems ---> non-informational character, not genetic system, cannot evolve by natural selection because they do not store information in a stable manner --- "they don't have genetic history"
For life, genetic replicating mechanism is required.
non-living ---------------> living
continuum
seamless
"meaningless to draw a line"
(his analogy: if you look at Mark Rothko's carefully, there is no clear boundary between lines)
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